Welcome to the LINXS mAb Final Meeting in Lund on September 25-26, 2024!
The LINXS mAb Final Meeting will be organized as a lunch-to-lunch event at LINXS in Lund.
We warmly welcome everybody who is interested in the work of the LINXS antibody consortium and its concerted experimental, simulation and theoretical effort to further the understanding of antibodies in solution and the progress achieved during the last couple of years.
The event comprises scientific presentations, perspectives from pharmaceutical industry and NIST (National Institute of Standards and Technology), as well as a round table discussion on ‘lessons learned and loose ends’.
There will be a limited number of seats available. Coffee, lunch and dinner will be served on-site.
Registration deadline is September 12th, 2024. Please note that we have a no-show fee of 200 SEK (for physical participation). If you can no longer attend, please email shandana.mufti@linxs.lu.se to avoid the fee.
Location: LINXS venue, IDEON Building: Delta 5 (5th floor), Scheelevägen 19, Lund
Programme
Wednesday afternoon, 25 September 2024
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12:15 – 13:15 |
Lunch |
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13:15 – 13:30 |
Welcome: Anna Stradner (Lund University & LINXS) |
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13:30 – 14:00 |
OP1: Robin Curtis (Univ. Manchester) “What can be learned from dilute solutions measurements of protein-protein interactions” |
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14:00 – 14:30 |
OP2: Peter Schurtenberger (Lund University) “Towards an improved colloid model for antibodies in solution” |
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14:30 – 15:00 |
OP3: Yun Liu (NIST, USA) “Protein-protein interactions and high-concentration solution viscosity of a monoclonal antibody: the effect of temperature” |
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15:00 – 15:30 |
Coffee break |
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15:30 – 16:00 |
OP4: Ralf Biehl (FZ Jülich) “Antibody domain dynamics: Search and Attack motions?” |
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16:00 – 16:30 |
OP5: Sergei Grudinin (Univ. Grenoble) “Atomic-scale modeling of antibodies: linking SAXS experiments with molecular simulations” |
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16:30 – 17:00 |
OP6: Emanuela Zaccarelli (Roma La Sapienza) & Fabrizio Camerin(Lund University) “Updates on coarse-grained antibody modelling” |
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17:00 – 17:30 |
OP7: Frank Delaglio (NIST, USA) “Characterizing mAb Expression, Structure, and Excipient Interactions by NMR Spectroscopy Using Spectral Modeling, Chemometrics, and Machine Learning” |
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17:30 – 18:00 |
OP8: Jure Cerar / Barbara Brannetti (Novartis, Basel) “The journey of a biologics from research to development: in-silico perspective” |
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18:00 – |
Dinner |
Thursday morning, 26 September 2024
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09:00 – 09:30 |
OP9: Andreas Stadler (FZ Jülich) “Multiscale dynamics of the NIST mAb studied by quasielastic neutron scattering” |
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09:30 – 10:00 |
OP10: Margarita Kruteva (FZ Jülich) “Diffusion NMR on monoclonal Antibodies” |
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10:00 – 10:30 |
OP11: Marco Polimeni (Lund University) “Modelling biomolecular interactions of mAb solutions” |
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10.30 – 11:00 |
Coffee break |
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11:00 – 11:10 |
Final Remarks Novartis: Karoline Bechtold-Peters (Novartis, Basel) |
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11:10 – 11:20 |
Final Remarks NIST: Katharina Yandrofski (NIST, USA) |
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11:20 – 12:15 |
Round table discussions: Lessons learned and loose ends (Dieter Richter (FZ Jülich) (chair); Karoline Bechtold-Peters (Novartis); Katharina Yandrofski / Yun Liu (NIST); Mikael Lund (Lund University)) |
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12:15 – 13:00 |
Lunch |
