Login

Scientific achievements through serial crystallography

22–24 Sept 2025
LINXS at The Loop
Europe/Stockholm timezone

For practical questions, please contact:

Session

Morning

24 Sept 2025, 08:30
LINXS at The Loop

LINXS at The Loop

Presentation materials

There are no materials yet.

  1. 52. Investigating enzyme mechanisms by multidimensional crystallography
    Pedram Mehrabi (University of Hamburg)
    24/09/2025, 09:00

    Functional characterization of proteins requires linking structure and dynamics, but traditional X-ray crystallography provides only static snapshots. Serial time-resolved crystallography enables direct visualization of structural changes over time, including internal motions and solvent interactions. We developed fixed-target approaches such as “Hit And REturn” (HARE) and reaction initiation...

    Go to contribution page
  2. 53. Time-resolved macromolecular crystallography studies of AmpCEC using synchrotron and XFEL radiation
    Emily Freeman (University of Oxford)
    24/09/2025, 09:30

    The β-lactamase enzymes degrade β-lactam antibiotics, exemplified by penicillin. As such, the families of metallo- and serine β-lactamases are responsible for a major antimicrobial resistance mechanism in many clinically relevant species of Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. To preserve the antimicrobial activity of β-lactam...

    Go to contribution page
  3. 54. Turning Up the Heat on Dynamic Proteins with Temperature-Jump X-ray Crystallography
    Michael Thompson (University of California, Merced)
    24/09/2025, 10:15

    Protein dynamics are critical for function, but it remains challenging to understand, in atomic detail, how a molecule’s biological activity is enabled by the physical coupling of its conformational fluctuations across varied length and time scales. Time-dependent X-ray crystallographic measurements of molecular structure can overcome some of the limitations of traditional structural biology...

    Go to contribution page
  4. 55. Serial Techniques for Weakly Scattering, In-Situ, and Dynamic Systems
    Mark Warren (Diamond Light Source)
    24/09/2025, 10:45
  5. 56. Serial Microsecond Crystallography with the ESRF Extremely Brilliant Source
    Daniele de Sanctis (ESRF - The European Synchrotron)
    24/09/2025, 11:15

    Time-resolved serial crystallography (TR-SX) is a leading technique for capturing biological processes as molecular movies on extremely fast timescales—fulfilling a long-standing goal in structural biology. The method involves delivering microcrystals into a powerful, pulsed X-ray beam to collect individual diffraction patterns from each crystal. By compiling thousands of these patterns,...

    Go to contribution page
  6. 57. Wrap-up
    24/09/2025, 11:45
Building timetable...