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Scientific achievements through serial crystallography

22–24 Sept 2025
LINXS at The Loop
Europe/Stockholm timezone

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Session

Tuesday

23 Sept 2025, 08:30
LINXS at The Loop

LINXS at The Loop

Presentation materials

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  1. 41. Time-resolved X-ray crystallography on membrane proteins: Watching ions moving in time and space
    Przemyslaw Nogly (Jagiellonian University in Krakow)
    23/09/2025, 09:00

    P. Nogly
    Dioscuri Centre for Structural Dynamics of Receptors, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland; przemyslaw.nogly@uj.edu.pl

    Chloride transport is an essential process maintaining ion balance across cell membranes, cell growth, and neuronal action potentials. However, the molecular mechanism of the transport remains elusive. Among...

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  2. 42. Using advanced crystallographic approaches to resolve how orange carotenoid protein photocycle works
    Volha Chukhutsina (Vrije Universiteit Amsterdam)
    23/09/2025, 09:30
  3. 43. GPCRs as Targets for Serial Crystallography
    Hannah Glover (leadXpro)
    23/09/2025, 10:00

    Using time-resolved serial crystallography to observe structural snapshots of protein dynamics at high resolution is a method that is becoming gradually more commonplace. Advancements in method development for this technique have allowed a wider range of proteins to be studied; looking at processes spanning endogenous photoresponses, enzyme kinetics and ligand binding. G protein-coupled...

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  4. 44. Serial femtosecond crystallography of high-valent metal sites and protein radicals
    Martin Högbom (Stockholm University)
    23/09/2025, 10:45

    Högbom, M 1

    1. Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden.

    High resolution structure determination methods suffer from problems with radiation damage. This is particularly problematic for radiation sensitive states such as high-valent metal sites and radicals. From a chemical perspective this means that some of the most relevant states for...

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  5. 45. Modeling X-ray-Induced Heating at 4th-Generation MX Beamlines
    Michal Kepa (Paul Scherrer Institute)
    23/09/2025, 11:15

    The transition from 3rd to 4th generation synchrotrons—featuring diffraction-limited storage rings—has significantly expanded future possibilities for macromolecular crystallography (MX). These upgrades, characterized by reduced source divergence and increased electron bucket capacity, have boosted brilliance by up to two orders of magnitude. As a result, next-generation MX beamlines, such as...

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  6. 46. Quantum refinement used for time-resolved crystallography
    Gayathri Yuvaraj (Lund University)
    23/09/2025, 11:45

    In standard crystallographic refinement of proteins, the experimental data are normally not enough to unambiguously decide the positions of all atoms. Therefore, the crystallographic data are supplemented by a set of empirical restraints that ensure that bond lengths and angles make chemical sense. To obtain more accurate results, we have suggested that this potential can be replaced by more...

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  7. 47. MicroMAX - Overview
    Jie Nan (MAX IV Laboratory)
    23/09/2025, 13:30

    The rise of 4th generation sources, including the MAX IV Laboratory 3 GeV ring, has enabled new possibilities to study dynamics using crystallography. The MicroMAX beamline is a new beamline focussed on providing optimal X-ray characteristics for serial (SSX) and time-resolved (TR-SSX) crystallography at MAX IV [1]. The beamline emphasizes a flexible sample environment for standard and bespoke...

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  8. 48. Sample delivery at MicroMAX
    Dean Lang (MAX IV Laboratory)
    23/09/2025, 13:50

    The rise of 4th generation sources, including the MAX IV Laboratory 3 GeV ring, has enabled new possibilities to study dynamics using crystallography. The MicroMAX beamline is a new beamline focussed on providing optimal X-ray characteristics for serial (SSX) and time-resolved (TR-SSX) crystallography at MAX IV [1]. The beamline emphasizes a flexible sample environment for standard and bespoke...

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  9. 49. Data analysis at MicroMAX
    Cecilia Casadei (MAX IV Laboratory)
    23/09/2025, 14:10

    The rise of 4th generation sources, including the MAX IV Laboratory 3 GeV ring, has enabled new possibilities to study dynamics using crystallography. The MicroMAX beamline is a new beamline focussed on providing optimal X-ray characteristics for serial (SSX) and time-resolved (TR-SSX) crystallography at MAX IV [1]. The beamline emphasizes a flexible sample environment for standard and bespoke...

    Go to contribution page
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