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Scientific achievements through serial crystallography

22–24 Sept 2025
LINXS at The Loop
Europe/Stockholm timezone

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Session

Monday

22 Sept 2025, 13:00
LINXS at The Loop

LINXS at The Loop

Presentation materials

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  1. 19. Welcome (Science Director Joachim Schnadt & MicroMAX Spokesperson Richard Neutze)
    Prof. Joachim Schnadt (MAX IV Laboratory), Prof. Richard Neutze (University of Gothenburg)
    22/09/2025, 13:00
  2. 20. Some questions can only be answered by time: how time-resolved crystallography reshapes structural biology
    Tobias Weinert (Paul Scherrer Institute)
    22/09/2025, 13:10

    Cryo-crystallography was the driving force of structural biology, literally deciphering the structures of life. The integrated knowledge has informed powerful machine learning technologies to not only solve the folding problem but to imagine new proteins, some of which are even functional. However, protein function is often dominated by small kinetic barriers that are not easily predicted....

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  3. 21. The potential for serial crystallography in drug discovery
    Helena Käck
    22/09/2025, 13:40

    Andreas Dunge (1,2), Gabrielle Wehlander (2), Gisela Brändén(2) and Helena Käck(1)
    1 Protein Sciences, Structure and Biophysics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; 2 Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE-405 30 Gothenburg, Sweden.

    Structure-based drug design has played a pivotal role in pharmaceutical...

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  4. 24. From Static to Dynamic: Evolving Methods in Protein Structure Determination
    Aina Cohen (Stanford Synchrotron Radiation Lightsource)
    22/09/2025, 14:40

    (representing the entire SSRL-SMB team)
    Structural Molecular Biology (SMB), Stanford Synchrotron Radiation Lightsource (SSRL), SLAC National Accelerator Laboratory, Stanford University, Menlo Park, United States of America

    Structural biologists are undertaking increasingly challenging projects including the study of membrane proteins and complex multi-component machines. Structural...

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  5. 25. Serial crystallography at the beamline P11, PETRA III
    Guillaume Pompidor (DESY)
    22/09/2025, 15:10

    P11 at PETRA III (DESY, Hamburg) is a high-throughput instrument for macromolecular crys-
    tallography [1]. The beamline has tuneable photon energy between 5.5 - 28 keV and and beam
    sizes from 200 x 200 μm to 4 x 9 μm2 can be used with a maximum photon flux of 1x1013 ph/s at
    12 keV energy. Equipped with a fast detector Eiger2 X 16M as the stationary detector (max 133 Hz),
    this high flux...

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  6. 26. Time-resolved crystallography of light-driven ion transporters at synchrotrons and free electron lasers
    Kirill Kovalev (EMBL-Hamburg)
    22/09/2025, 15:25

    Microbial rhodopsins constitute a large superfamily of light-sensitive membrane proteins, which are vital for numerous microorganisms on Earth, and for 20 years also being most-actively used in neuroscience and medicine in the biotechnology named optogenetics. The major role for optogenetics is played by ion-transporting rhodopsins. Understanding of their molecular mechanisms of functioning...

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  7. 27. Electrostatically Gated Enzyme Dynamics During Catalysis
    Mark Wilson (University of Nebraska–Lincoln)
    22/09/2025, 16:30

    Abstract: Enzyme catalysis is essential for life and is a central phenomenon in biochemistry. The advent of time-resolved serial crystallography, initially enabled by X-ray free electron lasers (XFELs) and now expanding to synchrotron X-ray sources, allows enzyme catalysis to be observed catalysis in real time, in near-physiological conditions, and at atomic resolution. I will describe our...

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  8. 28. Current and future capabilities for serial and time resolved crystallography at Diamond microfocus beamline VMXi
    Juan Sanchez Weatherby (Diamond Light Source)
    22/09/2025, 17:00

    There is increasing interest in obtaining room temperature, time resolved crystal structures of
    proteins carrying out their biological functions. The transition between conventional cryogenic
    macromolecular crystallography and serial crystallography involving microcrystals remains chal-
    lenging for many projects. We have recently demonstrated the capability to measure good quality,
    low dose...

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