4–6 Jun 2018
Skissernas Museum
Europe/Stockholm timezone

Contributed talk 6 - Low radiation dose XPCS for dynamic studies of biological matter

5 Jun 2018, 16:50
20m
Skissernas Museum

Skissernas Museum

Finngatan 2 223 62 Lund Sweden
Oral presentation Dynamics of proteins in crowded and confined geometry Dynamics of Proteins in Crowded and Confined Geometry

Speaker

Prof. Christian Gutt (University Siegen)

Description

X-ray photon correlation spectroscopy (XPCS) measures nanoscale dynamics in real time by correlations of X-ray speckle patterns. The speckle patterns yield access to density-density correlation functions and also to higher order correlation functions. However, the highly intense X-ray beams of modern storage rings are also the cause for considerable radiation damage to the samples. Traditionally, XPCS experiments are performed with radiation doses of MGy to GGy, many orders of magnitude higher than tolerable for biological samples. We demonstrated recently [1] that XPCS experiments can be performed with very low doses reaching doses as low as a few kGy which opens the possibility to study dynamics of protein systems. In this talk I will present the methodology, opportunities, challenges and also first results of XPCS studies of radiation sensitive samples.

[1] J. Verwohlt et al. Phys Rev Lett 120, 168001 (2018)

Authors

Prof. Christian Gutt (University Siegen) Jan Verwohlt Mario Reiser (XFEL) Lisa Randolph Anders Madsen (XFEL) Aleksandar Matic (Physics Gothenborg) Michael Sprung (DESY)

Presentation materials

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