During the round table discussions at the LINXS workshop on the “Dynamics of Biological Macromolecules” in June 2018, the characterization and understanding of the static and dynamic properties of antibody solutions received particular attention. It clearly emerged as one of the highly timely topics where LINXS could and should play a central role and help the community to overcome certain obstacles such as access to sufficiently large quantities of high-quality material.
The Research Programme “Antibodies in Solution” has now secured sufficient quantities of several monoclonal antibodies and brings together experimentalists, theoreticians and simulators from all over the world to work on the characterization of these antibodies in a coherent, efficient and synergistic way. The main emphasis is the creation of a reference set of data for several mAbs that can then be used to validate theoretical models and simulations on different levels of coarse graining.
This kick-off meeting brings together the different experimental and theoretical working groups to get to know each other and to discuss the best possible ways to launch out into this challenging venture.