Time Resolved Structural Biology – Seeing the structure of motions

Europe/Stockholm
Digital meeting on Zoom
Description


Join us online for a workshop from Monday (Nov 23) to Wednesday (Nov 25) with programme 13h - 18h CET each day.

This workshop will cover different aspects of studying the molecular structure of biological macromolecules using time-resolved experimental techniques or computational methods - What can we learn? What method is best for a certain question and how do they complement each other? The workshop aims to broaden concepts of time-resolved structural biology and it will encourage discussion between the participants.

When: Nov 23 - Nov 25
Dates are fixed - the workshop will be fully digital.
Where: online

Abstracts: We welcome abstract submissions. A few abstracts will be selected for oral presentations. We also plan to have posters online. The deadline for abstracts is Nov. 1.

Speakers

Abbas Ourmazd - University of Wisconsin-Milwaukee, "Dynamics by Machine Learning"
Sebastian Westenhoff - University of Gothenburg, "Photoactivation of the "eyes" of plants"
Ana-Nicoleta Bondar - Freie Universität Berlin, "How dynamic hydrogen-bond networks shape protein conformational plasticity of GPCRs and SARS-CoV-2 spike protein S"
Hongyi Xu - Stockholm University, “Electron Diffraction Methods for Structure Determination of Biomolecules
Jakob Andreasson - ELI Beamlines, "Ultrafast dynamics investigated by laser-driven light-sources at the Extreme Light Infrastructure"
Jörg Standfuss - Paul Scherrer Institute, "Time-resolved serial crystallography using synchrotrons and X-ray lasers - Rhodopsins pave the way to a dynamic future"
Linda C Johansson - University of Gothenburg, "Structure-function of the human melatonin receptors and potential for time-resolved studies
Jörg Pieper - University of Tartu, "Insights into structure and dynamics of photosynthetic protein complexes from neutron scattering experiments"
Radoslav Enchev - The Francis Crick Institute, "Time-Resolved Analysis by Cryo-Electron Microscopy”
Mikael Akke - Lund University, “Dynamic allosteric communication pathway in the glucocorticoid receptor directs its differential activation by ligands and coregulators
Gleb Bourenkov - EMBL@PETRA III, Hamburg, "Development of time-resolved synchrotron crystallography at EMBL/P14"
Vania Calandrini - Forschungszentrum Juelich, "An Open-Boundary Molecular Mechanics/Coarse-Grained Framework for Simulations of Low-Resolution G-Protein-Coupled Receptor–Ligand Complexes"
Ran Friedman - Linnaeus University, Kalmar, “Computer simulations of kinases - the challenge in resolving enzyme activation

Organizers

LINXS working group in Time-Resolved Structural Biology, with support from the Biocompute and Dynamics working groups.

The registration deadline is on November 1.

For practical questions, please contact:
    • 13:00 13:10
      Introduction 10m
    • 13:10 13:50
      Invited talk 1: Dynamics by Machine Learning 40m
      Speaker: Abbas Ourmazd (University of Wisconsin-Milwaukee)
    • 13:50 14:30
      Invited talk 2: Structure-function of the human melatonin receptors and potential for time-resolved studies 40m
      Speaker: Linda C Johansson (University of Gothenburg)
    • 14:30 14:50
      Coffee Break 20m
    • 14:50 15:10
      Contr. talk 1: Tracking ATP binding by adenylate kinase using time-resolved X-ray solution scattering 20m
      Speaker: Magnus Andersson (Umeå University)
    • 15:10 15:50
      Invited talk 3: Dynamic allosteric communication pathway in the glucocorticoid receptor directs its differential activation by ligands and coregulators 40m
      Speaker: Mikael Akke (Lund University)
    • 15:50 16:30
      Invited talk 4: Photoactivation of the "eyes" of plants 40m
      Speaker: Sebastian Westenhoff (University of Gothenburg)
    • 16:30 16:40
      Short Coffee Break 10m
    • 16:40 17:00
      Contr. talk 2: Towards time-resolved protein dynamics on nanoscopic scales 20m
      Speaker: Felix Roosen-Runge (Department for Biomedical Science, Malmö University)
    • 17:00 17:30
      Invited talk 5: An Open-Boundary Molecular Mechanics/Coarse-Grained Framework for Simulations of Low-Resolution G-Protein-Coupled Receptor–Ligand Complexes 30m
      Speaker: Vania Calandrini (Forschungszentrum Juelich, Germany)
    • 13:00 13:40
      Invited talk 6: Time-resolved serial crystallography using synchrotrons and X-ray lasers - Rhodopsins pave the way to a dynamic future 40m
      Speaker: Jörg Standfuss (Paul Scherrer Institute, Switzerland)
    • 13:40 14:00
      Contr. talk 3: Integrative time-resolved structural biology of the light-regulated transcription factor EL222 20m
      Speaker: Gustavo Fuertes
    • 14:00 14:40
      Invited talk 7: Applications in structural dynamics at the ELI Beamlines user facility 40m

      Applications in structural dynamics at the ELI Beamlines user facility
      Located in Dolni Brezany, next to Prague in the Czech Republic, the ELI Beamlines facility develops state of the art, high intensity, lasers for fundamental and applied research. As a user facility ELI Beamliens will make high intensity lasers, laser driven XUV, X-ray and particle sources available for the international user community
      Within ELI Beamlines the objective of the Department of Structural Dynamics is to develop and operate user stations for research into the structure, dynamics and function of samples ranging from isolated atoms to complex biological samples and the solid state using ultrashort pulses from laser-driven XUV / X-ray sources as well as pulses from the primary infrared lasers. A key advantage of the ELI Beamlines facility is in the possibility to utilize unique combinations of lasers and laser driven sources with near-perfect synchronization. This makes it possible to carry out demanding pump-probe experiments, with the particular aim at understanding the complex dynamics underpinning advanced functions or fundamental processes. Users will be able to study the mechanisms of physical, chemical and biological processes at the atomic level and on time scales ranging from femto- to milliseconds, study and control electronic processes and study complex systems in a range of environments. Central experimental technologies include time-resolved diffraction, scattering and imaging techniques, optical (IR to DUV), XUV and X-ray spectroscopy. Instruments presently available for user experiments, or in an advanced commissioning state are:
      A multi purpose end station for AMO science and Coherent Diffractive imaging
      Ultrafast optical spectroscopy:
      -Femtosecond Stimulated Raman Scattering and transient optical absorption.
      -Time resolved spectroscopic ellipsometry.
      -IR spectroscopy
      A station for X-ray experiments, in particular diffraction/scattering and spectroscopy

      Speaker: Jakob Andreasson (ELI Beamlines)
    • 14:40 15:10
      Panel discussion 30m
    • 15:10 15:30
      Coffee Break 20m
    • 15:30 16:10
      Invited talk 8: How dynamic hydrogen-bond networks shape protein conformational plasticity of GPCRs and SARS-CoV-2 spike protein S 40m
      Speaker: Ana-Nicoleta Bondar (Freie Universität Berlin)
    • 16:10 16:50
      Invited talk 9: Insights into structure and dynamics of photosynthetic protein complexes from neutron scattering experiments 40m
      Speaker: Jörg Pieper (University of Tartu)
    • 16:50 17:40
      Poster session 50m
    • 13:00 13:40
      Invited talk 10: Time-Resolved Analysis by Cryo-Electron Microscopy 40m
      Speaker: Radoslav Enchev (The Francis Crick Institute)
    • 13:40 14:00
      Contr. talk 4: Utilizing pH-driven time-resolved crystallography to elucidate the reaction mechanism in bacterial HMG-CoA reductase. 20m
      Speaker: Vatsal Purohit (Purdue University)
    • 14:00 14:40
      Invited talk 11: Electron Diffraction Methods for Structure Determination of Biomolecules 40m
      Speaker: Hongyi Xu (Stockholm University)
    • 14:40 15:10
      Coffee Break 30m
    • 15:10 15:40
      Invited talk 12: Development of time-resolved synchrotron crystallography at EMBL/P14 30m
      Speaker: Gleb Bourenkov (EMBL@PETRA III, Hamburg)
    • 15:40 16:00
      Contr. talk 5: Unraveling structural intermediates in ba3-type cytochrome c oxidase using time- resolved X-ray methods 20m
      Speaker: Swagatha Ghosh (University of Gothenburg)
    • 16:00 16:30
      Invited talk 13: Computer simulations of kinases - the challenge in resolving enzyme activation 30m
      Speaker: Ran Friedman (Linnaeus University, Kalmar)
    • 16:30 16:50
      Wrap-up 20m
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