2nd LINXS Symposium on Integrative Structural Biology

Session

Keynotes and Short talks 8

11 Oct 2019, 10:50

Auditorium (Kulturen)

23. Short Talk 12, Magnus Andersson - Tracking Ca2+ ATPase Intermediates in Real-Time by X-ray Solution Scattering

Magnus Andersson (Umeå University)

11/10/2019, 10:50

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) transporters regulate calcium signaling by active calcium
ion reuptake to internal stores. Several of the structural transitions associated with transport have been characterized
by X-ray crystallography, but critical intermediates of the inward-outward switching are missing.
We combined time-resolved X-ray solution scattering (TR-XSS)...

24. Keynote 10, Prof Erik Lindahl: Deciphering Allosteric Modulation in Ligand-Gated Ion Channels with Simulations, X-ray crystallography, Cryo-EM and Neutron Scattering

Prof. Erik Lindahl (Stockholm University)

11/10/2019, 11:10

Ligand-gated ion channels control the electrical excitation of nerve cells, in particular in the post-synaptic membrane in response to chemical signals mediated by neurotransmitters. These receptors exhibit an amazing diversity in detailed structure and function - some human channels have 15-20 slightly genes, and with five subunits this can theoretically lead to almost a million different...