In my laboratory we combine crystallographic, biophysical, electron and light microscopy based approaches into integrated structural biology analyses to study the assembly and modulation of cell surface signalling complexes involved in development and tissue homeostasis. We aim to generate mechanistic insights, at atomic resolution, which can be tested by functional studies in vitro and in...
Multidrug resistance in bacteria, originating from conjugative gene transfer, is an increasingly common problem
in today’s world. The majority of bacteria that causes hospital infections are of gram-positive origin,
but so far very little is known about their conjugation systems. To remedy this, we aim to determine the
molecular structure and function of conjugation complexes belonging to Type...
The human genome project and subsequent sequencing efforts of thousands of patients and healthy individual provides a wealth of associations between variants in genes and diseases. At the SGC our aim is to create a step-change in drug development by providing tools (proteins, structures, assays and bound small molecules), for proteins that are have associations with genetic disease. We focus...
