Conveners
Membrane Dynamics and Protein Interactions: Morning session
- Marite Cardenas (Malmö University)
Membrane Dynamics and Protein Interactions: Morning session
- Marite Cardenas (Malmö University)
The properties of self-assembled amphiphilic molecules are of key relevance to understanding the complex processes that take place in biological membranes. Albeit structural characterization being the initial step to understanding such systems, ultimately the dynamics over a wider range of timescales are key to understanding function and the interactions tha take place between the multitude of...
The stratum corneum is the outermost layer of human skin and primary barrier towards the environment. The main component is stacked layers of saturated long-chain ceramides, free fatty acids and cholesterol, but we do not yet know the molecular structure or formation details. Here, I will present our work on new methods to fit models to low-resolution cryo-EM microscopy vitreous section...
Arginine-rich cell-penetrating peptides (RRPs) spontaneously traverse cell mem-
branes and are promising candidates for drug delivery. The internalization mechanism has been suggested to involve a cooperative process initiated by the self-aggregation of RRPs adsorbed onto the plasma membrane1. Likewise, formation of aggregates in solution has been shown to be related to the efficiency of...
Membrane curvature generation and membrane remodeling underlie many biological processes such as virus entry into cells and virus budding. How proteins mediate this curvature generation is a fundamental question that is still poorly understood. I will present our recent structural studies, using solid-state NMR spectroscopy, of three membrane proteins that give insights into the mechanisms of...
