Conveners
Biointerfaces: Afternoon sessions
- Peter Jönsson (Physical Chemistry, Lund University)
Biointerfaces: Afternoon sessions
- Peter Jönsson (Physical Chemistry, Lund University)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. For this purpose we employ the combination of experimental techniques in real and reciprocal spaces, including grazing...
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins,...
In atherosclerosis lipids and fibrous elements accumulate in the blood vessels forming plaques that eventually can lead to myocardial infarction or stroke. HDL and LDL particles have been shown to play a role in the development and the progression of the plaque build-up and are currently used as biological markers in addition to measurements of total lipid and cholesterol. Yet many people...
Virus entry is a complex dynamic multistep process requiring a series of fine-tuned events mediating virus diffusion through the glycocalyx, its attachment to the cell membrane and lateral diffusion to the point of entry. This is followed by entry, involving membrane fusion or membrane deformation into an endocytic vesicle.
The aim of our research is elucidate the mechanisms by which viral...
Lipid membranes, which are the most biologically relevant lipid aggregates, have a bilayer structure. Still, in a human body, there are two important lipid assemblies, Lung Surfactant (LS) and Tear Film Lipid Layer (TFLL), which have not bi- but rather a multilayer character. Lung surfactant lines the gas-exchange interface in the lung alveoli and reduces the surface tension at the air-liquid...
Amphotericin B (AmB) is a naturally occurring antibiotic with a broad spectrum against systemic fungal and parasitic infections. AmB interacts preferentially with ergosterol in cell membranes, giving rise to the fungal specificity, but it also interacts with a lower affinity with cholesterol, giving rise to toxic side effects that are often dose-limiting. The classical AmB mechanism is based...
Cyanobacteria are relative simple unicellular photosynthetic prokaryotes, considered ancestors of higher plant chloroplasts. We have investigated thylakoid stacking and dynamics of three cyanobacterial species with various thylakoid arrangements in vivo by means of small-angle scattering and have correlated it to the results of transmission electron microscopy.
We have formulated a...
Biological membranes are intrinsically out-of-thermal equilibrium, driven by a vast range of external forces, excerted for example by motor proteins, ion channels, or interactions with other membranes such as in membrane fusion. We woul like to gain a quantitative understanding in the generic differenced of membrane dynamics under such out-of-equilibrium conditions. To this end, we have used...
