What: LINXS Amyloid workshop - Heart, Brain and Mind
When: March 3-4, 2022
Where: Hybrid workshop with either digital or on-site participation
Registration deadline: February 15, 2022
AIMS
Amyloid diseases are caused by the aggregation of proteins and their accumulation as amyloid fibrils in cells and tissues. Much research is focused on understanding the basic biology of amyloidosis and how it relates to disease etiology. Integrative structural biology is an integral part in order to achieve this but also very challenging. The workshop will therefore address synergy and conflict of technology (reduction) for medical complexity (integration)
WHO SHOULD PARTICIPATE?
The workshop wishes to bring to together basic researchers and clinicians to discuss existing and novel experimental approaches to determine amyloid structures and integrating the results to explain medical problem. The participants may have specific knowledge in methodology that relates to the different topics, or may have a specific biological or medical research questions that can be addressed by structure analysis methods.
Open to young/early career researchers as well as more senior.
TOPICS:
1. Historical overview of clinics (amyloids)
2. Historical overview of therapeutics, stabilization story? interference of aggregation (how our best molecular knowledge used?), side effects to consider?
3. Translational aspects of misfolding dynamics to in vivo (most critical points of in vitro to in vivo)
4. How to cover the gap between basic research and clinics?
5. How to cover gap with industry?
CONFIRMED SPEAKERS
Sheena Radford - University of Leeds, UK
Laura Obici - IRCCS Fondazione Policlinico San Matteo, Italy
Julian Gillmore - Royal Free Hospital London, UK
Per Westermark - Uppsala University, Sweden
Jens Lagersted - Novo Nordisk A/S, Denmark
