Dynamics of Biological Macromolecules

Session

Protein Dynamics and Drug Discovery

PDDD

5 Jun 2018, 17:10

Skissernas Museum

70. KEYNOTE 11 - Neutron scattering and drug discovey

Prof. Jeremy Smith ( Oak Ridge National Laboratory)

05/06/2018, 17:10

Protein dynamics and drug discovery

Oral presentation

Neutron scattering, when combined with computational science, can aid in the drug discovery process in several ways. We illustrate how precision neutron crystallography can permit the derivation of the thermodynamic driving forces behind the binding of drugs to their targets. Also, we show how computational drug design protocols benefit considerably from a dynamic, rather than just a static,...

74. KEYNOTE 13 - Improving the accessibility of time-resolved structural biology: new photochemical tools and data collection strategies

Prof. Arwen Pearson (University of Hamburg)

06/06/2018, 11:10

Protein dynamics and drug discovery

Oral presentation

Proteins have evolved into complex nanomachines able to couple dynamics over
many orders of magnitude in time to precisely and exquisitely control
chemical reactions and processes such as signal transfer and the generation
of mechanical force. To understand how they are able to achieve this
requires not only the determination of their structure, but also study of
their dynamics. Time-resolved...

37. Contributed Talk 10

Protein dynamics and drug discovery

Oral presentation

43. Contributed Talk 11

Oral presentation

39. Contributed Talk 12

Protein dynamics and drug discovery

Oral presentation

40. Contributed Talk 13

Protein dynamics and drug discovery

Oral presentation

44. KEYNOTE 11 - Neutron scattering and drug discovery

Prof. Jeremy Smith ( Oak Ridge National Laboratory)

38. KEYNOTE 13 - Photocages and beamlines: new tools for time-resolved structural biology

Prof. Arwen Pearson (University of Hamburg)

Protein dynamics and drug discovery