Dynamics of Biological Macromolecules

Session

Antibody Dynamics and Internal Motion in Proteins

ADIMP

4 Jun 2018, 17:05

Skissernas Museum

45. Contributed talk 3 - Efficient Prediction of Macromolecular Flexibility and its Applications to Small-Angle Scattering

Sergei Grudinin (Inria / CNRS)

04/06/2018, 17:05

Antibody dynamics and internal motion in proteins

Oral presentation

Large macromolecular machines, such as proteins and their complexes, are typically very flexible at physiological conditions. Computationally, this flexibility can be approximated with just a few collective molecular motions, computed e.g. using the Normal Mode Analysis (NMA). NMA determines low-frequency motions at a very low cost and these are particularly interesting to the structural...

63. KEYNOTE 5 - Neutron Spinecho Spectroscopy: Protein internal dynamics, forces and friction

Dr Ralf Biehl (Forschungszentrum Jülich)

05/06/2018, 08:30

Antibody dynamics and internal motion in proteins

Oral presentation

The biological function of proteins is often related to large-scale domain motions, which are induced or suppressed by the binding of a substrate or due to cosolvents. Domain motions can be related to soft hinges, flexible linker regions or -as in the case of intrinsic unfolded proteins- be native to the unfolded protein structure. These large-scale domain motions in solution cannot be...

48. KEYNOTE 6 - Combining scattering and coarse-grained molecular models to quantify and predict thermodynamic and dynamic contributions to antibody self-interactions and solution properties

Prof. Christopher Roberts

05/06/2018, 09:10

Antibody dynamics and internal motion in proteins

Oral presentation

Protein-protein interactions can influence a range of material properties and dynamic/kinetic behaviors, from aggregation kinetics to solution viscosity, self-association, and solubility. This presentation focuses on dilute and concentrated solutions of monoclonal antibodies and synthetic antibodies, from the perspective of predicting the physical properties and/or behavior of these systems...

58. Contributed talk 4 - Short-time self-diffusion of immunoglobulin under different crowding conditions

Marco Grimaldo (Institut Laue-Langevin)

05/06/2018, 09:50

Antibody dynamics and internal motion in proteins

Oral presentation

Approximately 10-40% of the intra- and extracellular fluids of living organisms is occupied by macromolecules such as proteins, the internal dynamics of which is widely recognized as a crucial aspect for their function. The rather high concentration of such macromolecules is known as “macromolecular crowding” and was shown to influence reaction rates [1] and protein thermal stability. Here, we...

68. KEYNOTE 7 - Computer simulations of antibody solutions: from structure to dynamics?

Prof. Emanuela Zaccarelli (University of Rome La Sapienza)

05/06/2018, 10:40

Antibody dynamics and internal motion in proteins

Oral presentation

Concentrated solutions of monoclonal antibodies have attracted considerable attention due to their importance in pharmaceutical formulations, yet their tendency to aggregate and the resulting high solution viscosity has posed considerable problems. It remains a very difficult task to understand and predict the solution behavior and stability of such solutions.
In this talk I will discuss a...

75. Contributed Talk 3: Efficient Prediction of Macromolecular Flexibility and its Applications to Small-Angle Scattering

Sergei Grudinin (Inria / CNRS)

23. Contributed Talk 4: Short-time self-diffusion of immunoglobulin under different crowding conditions

Marco Grimaldo (Institut Laue-Langevin)

Antibody dynamics and internal motion in proteins

Oral presentation

26. Contributed Talk 6

Antibody dynamics and internal motion in proteins

Oral presentation

27. Contributed Talk 7

Antibody dynamics and internal motion in proteins

Oral presentation

21. KEYNOTE 5 - Neutron Spinecho Spectroscopy: Protein internal dynamics, forces and friction

Dr Ralf Biehl (Forschungszentrum Jülich)

Antibody dynamics and internal motion in proteins

22. KEYNOTE 6 - Combining scattering and coarse-grained molecular models to quantify and predict thermodynamic and dynamic contributions to antibody self-interactions and solution

Prof. Christopher Roberts (University of Delaware)

Antibody dynamics and internal motion in proteins

28. KEYNOTE 7 - Computer simulations of antibody solutions: from structure to dynamics?

Prof. Emanuela Zaccarelli (University of Rome La Sapienza )

Antibody dynamics and internal motion in proteins