Introduction

Invited talk 1: Dynamics by Machine Learning

• Abbas Ourmazd (University of Wisconsin-Milwaukee)

Invited talk 2: Structure-function of the human melatonin receptors and potential for time-resolved studies

• Linda C Johansson (University of Gothenburg)

Contr. talk 1: Tracking ATP binding by adenylate kinase using time-resolved X-ray solution scattering

• Magnus Andersson (Umeå University)

Invited talk 3: Dynamic allosteric communication pathway in the glucocorticoid receptor directs its differential activation by ligands and coregulators

• Mikael Akke (Lund University)

Invited talk 4: Photoactivation of the "eyes" of plants

• Sebastian Westenhoff (University of Gothenburg)

Contr. talk 2: Towards time-resolved protein dynamics on nanoscopic scales

• Felix Roosen-Runge (Department for Biomedical Science, Malmö University)

Invited talk 5: An Open-Boundary Molecular Mechanics/Coarse-Grained Framework for Simulations of Low-Resolution G-Protein-Coupled Receptor–Ligand Complexes

• Vania Calandrini (Forschungszentrum Juelich, Germany)

Invited talk 6: Time-resolved serial crystallography using synchrotrons and X-ray lasers - Rhodopsins pave the way to a dynamic future

• Jörg Standfuss (Paul Scherrer Institute, Switzerland)

Contr. talk 3: Integrative time-resolved structural biology of the light-regulated transcription factor EL222

• Gustavo Fuertes

Invited talk 7: Applications in structural dynamics at the ELI Beamlines user facility

• Jakob Andreasson (ELI Beamlines)

Applications in structural dynamics at the ELI Beamlines user facility Located in Dolni Brezany, next to Prague in the Czech Republic, the ELI Beamlines facility develops state of the art, high intensity, lasers for fundamental and applied research. As a user facility ELI Beamliens will make high intensity lasers, laser driven XUV, X-ray and particle sources available for the international user community Within ELI Beamlines the objective of the Department of Structural Dynamics is to develop and operate user stations for research into the structure, dynamics and function of samples ranging from isolated atoms to complex biological samples and the solid state using ultrashort pulses from laser-driven XUV / X-ray sources as well as pulses from the primary infrared lasers. A key advantage of the ELI Beamlines facility is in the possibility to utilize unique combinations of lasers and laser driven sources with near-perfect synchronization. This makes it possible to carry out demanding pump-probe experiments, with the particular aim at understanding the complex dynamics underpinning advanced functions or fundamental processes. Users will be able to study the mechanisms of physical, chemical and biological processes at the atomic level and on time scales ranging from femto- to milliseconds, study and control electronic processes and study complex systems in a range of environments. Central experimental technologies include time-resolved diffraction, scattering and imaging techniques, optical (IR to DUV), XUV and X-ray spectroscopy. Instruments presently available for user experiments, or in an advanced commissioning state are: A multi purpose end station for AMO science and Coherent Diffractive imaging Ultrafast optical spectroscopy: -Femtosecond Stimulated Raman Scattering and transient optical absorption. -Time resolved spectroscopic ellipsometry. -IR spectroscopy A station for X-ray experiments, in particular diffraction/scattering and spectroscopy

Invited talk 8: How dynamic hydrogen-bond networks shape protein conformational plasticity of GPCRs and SARS-CoV-2 spike protein S

• Ana-Nicoleta Bondar (Freie Universität Berlin)

Invited talk 9: Insights into structure and dynamics of photosynthetic protein complexes from neutron scattering experiments

• Jörg Pieper (University of Tartu)

Invited talk 10: Time-Resolved Analysis by Cryo-Electron Microscopy

• Radoslav Enchev (The Francis Crick Institute)

Contr. talk 4: Utilizing pH-driven time-resolved crystallography to elucidate the reaction mechanism in bacterial HMG-CoA reductase.

• Vatsal Purohit (Purdue University)

Invited talk 11: Electron Diffraction Methods for Structure Determination of Biomolecules

• Hongyi Xu (Stockholm University)

Invited talk 12: Development of time-resolved synchrotron crystallography at EMBL/P14

• Gleb Bourenkov (EMBL@PETRA III, Hamburg)

Contr. talk 5: Unraveling structural intermediates in ba3-type cytochrome c oxidase using time- resolved X-ray methods

• Swagatha Ghosh (University of Gothenburg)

Invited talk 13: Computer simulations of kinases - the challenge in resolving enzyme activation

• Ran Friedman (Linnaeus University, Kalmar)